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dc.contributor.advisorRealpe, Teresa
dc.contributor.authorRealpe, Teresa
dc.contributor.authorCorrea, Nidia
dc.contributor.authorCarlos Rozo, Juan
dc.contributor.authorFerro, Beatriz Elena
dc.contributor.authorGomez, Verónica
dc.contributor.authorZapata, Elsa
dc.contributor.authorRibon, Wellman
dc.contributor.authorPuerto, Gloria
dc.contributor.authorCastro, Claudia
dc.contributor.authorNieto, Luisa María
dc.contributor.authorDiaz, Maria Lilia
dc.contributor.authorRivera, Oriana
dc.contributor.authorCouvin, David
dc.contributor.authorRastogi, Nalin
dc.contributor.authorArbelaez, Maria Patricia
dc.contributor.authorRobledo, Jaime
dc.date.accessioned2020-01-15T21:15:05Z
dc.date.available2020-01-15T21:15:05Z
dc.date.issued2014
dc.identifier.urihttps://hdl.handle.net/20.500.12692/39832
dc.description.abstractBackground: Phylogeographic composition of M. tuberculosis populations reveals associations between lineages and human populations that might have implications for the development of strategies to control the disease. In Latin America, lineage 4 or the Euro-American, is predominant with considerable variations among and within countries. In Colombia, although few studies from specific localities have revealed differences in M. tuberculosis populations, there are still areas of the country where this information is lacking, as is a comparison of Colombian isolates with those from the rest of the world. Principal Findings: A total of 414 M. tuberculosis isolates from adult pulmonary tuberculosis cases from three Colombian states were studied. Isolates were genotyped using IS6110-restriction fragment length polymorphism (RFLP), spoligotyping, and 24-locus Mycobacterial interspersed repetitive units variable number tandem repeats (MIRU-VNTRs). SIT42 (LAM9) and SIT62 (H1) represented 53.3% of isolates, followed by 8.21% SIT50 (H3), 5.07% SIT53 (T1), and 3.14% SIT727 (H1). Composite spoligotyping and 24-locus MIRU- VNTR minimum spanning tree analysis suggest a recent expansion of SIT42 and SIT62 evolved originally from SIT53 (T1). The proportion of Haarlem sublineage (44.3%) was significantly higher than that in neighboring countries. Associations were found between M. tuberculosis MDR and SIT45 (H1), as well as HIV-positive serology with SIT727 (H1) and SIT53 (T1). Conclusions: This study showed the population structure of M. tuberculosis in several regions from Colombia with a dominance of the LAM and Haarlem sublineages, particularly in two major urban settings (Medellı ´n and Cali). Dominant spoligotypes were LAM9 (SIT 42) and Haarlem (SIT62). The proportion of the Haarlem sublineage was higher in Colombia compared to that in neighboring countries, suggesting particular conditions of co-evolution with the corresponding human population that favor the success of this sublineage.en_US
dc.description.uriTrabajo académicoes_PE
dc.formatapplication/pdfes_PE
dc.language.isoenges_PE
dc.publisherUniversidad César Vallejoes_PE
dc.relationinfo:eu-repo/semantics/articlees_PE
dc.relation.ispartofseriesPLOS ONE;
dc.rightsinfo:eu-repo/semantics/openAccesses_PE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/es_PE
dc.sourceRepositorio Institucional - UCVes_PE
dc.sourceUniversidad César Vallejoes_PE
dc.subjectPulmones - enfemedadeses_PE
dc.subjectTuberculosis - prevenciónes_PE
dc.subjectTuberculosises_PE
dc.titlePopulation structure among Mycobacterium tuberculosis Isolates from pulmonary tuberculosis patients in Colombiaes_PE
dc.typeinfo:eu-repo/semantics/monographes_PE
thesis.degree.disciplineEnfermeríaes_PE
thesis.degree.grantorUniversidad César Vallejo. Facultad de Ciencias de la Saludes_PE
thesis.degree.nameLicenciada en Enfermeríaes_PE
dc.description.sedeLima Nortees_PE
dc.description.lineadeinvestigacionTuberculosises_PE
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0093848
renati.levelhttps://purl.org/pe-repo/renati/level#tituloProfesionales_PE
renati.typehttps://purl.org/pe-repo/renati/type#trabajoAcademicoes_PE


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